CBD For Inflammation: Benefits, Scientific Studies, & CBD Dosage For Inflammation

CBD offers a number of therapeutic and medicinal properties. While it may be a newly discovered remedy for many medical conditions, research into its anti-inflammatory properties is pretty thorough, indicating that the use of CBD for inflammation and for inflammatory diseases can be a very promising solution.

What Is Inflammation?

InflammationInflammation is a complex biological response of body tissues to harmful stimuli. These stimuli can be in the form of irritants, injury, damaged cells, pathogens, stress or toxins.

The process of inflammation is initiated in order to eliminate the initial cause of injury, clear out the damaged cells and to start tissue repair. The signs of inflammation are heat, redness, pain, swelling, and loss of function.

Inflammation is a very important immune response, which not only helps to destroy harmful stimuli (microbes, pathogens, irritants) but also plays a key position in the survival of an organism.

While the normal inflammatory response is very consequential in the body’s functioning, chronic inflammation, which persists for longer durations, causes simultaneous destruction and healing of the tissue, necrosis (localized death of cells or tissues) and fibrosis (formation of excess fibrous tissue in an organ), thus creating a lot of health issues.

What Are Inflammatory Conditions for Which One Can Use CBD?

Inflammatory diseases such as Rheumatoid arthritis, autoimmune diseases, diabetes, inflammatory bowel diseases and many types of cancer can be treated using CBD.

A survey has found that almost 20% of the U.S population (43 million people) suffer from arthritis and joint diseases. This number is expected to surpass 60 million by 2020. It is also known that nearly 24 million Americans (8% of the population) are affected by diabetes.

Estimates are that by 2025, the number of Americans with the disease will be close to 50 million. Considering these facts it becomes very important to have a substance with minimal side effects in the treatment regimen of these inflammatory conditions.

These rising statistics and the fact that inflammation is the underlying cause in most of the cases cannot be neglected. Researchers are, therefore, trying to find a medicine, which not only treats inflammatory diseases but also helps prevent them.

This is where the role of CBD, which is a cannabinoid that comes from a natural plant, is brought into the light. The compound is attributed as a natural cure for inflammation and many of the conditions associated with it.

How Does CBD Help Treat Inflammation And Inflammatory Diseases?

The numerous health benefits of CBD, along with its effects on a broad array of conditions, have caused an increasingly large population of people to turn to CBD for inflammation treatment and management.

The cannabinoid has become a rising star, not only amongst patients but also among research authorities. It is being extensively studied for its therapeutic and pharmacological properties.

Studies have found that the compound delivers its effects by interfering with the normal functioning of the endocannabinoid system (CB1 and CB2 receptors), which is responsible in controlling a range of biological activates such as stress, pain, mood, thinking capacities, metabolism, and inflammatory responses.

Researchers have also suggested that CBD affects immune responses and host resistance by perturbing the balance between the cytokines (signaling proteins synthesized and secreted by immune cells upon stimulation) produced by T-helper subsets, thus interfering with the process of initiation and resolution of inflammation.

What Are The Scientific Studies That Point Towards CBD Use In Inflammatory Conditions?

In a study published in August 2000, the authors showed that CBD, through its combined immunosuppressive and anti-inflammatory actions, had a potent anti-arthritic effect.

The study, which involved a daily 5 mg/kg oral or 25 mg/kg intraperitoneal administration of CBD to mice, indicated that the compound was significantly beneficial in inhibiting disease progression.

The study also demonstrated that CBD-treated mice had less, proliferation in ex vivo-activated draining lymph node cells, decreased levels of IFN-γ secreted by the activated lymph node cells and diminished TNF-α production by knee synovial cells.

In another study conducted in July 2016, it was shown that topical CBD application had therapeutic potential for relief of arthritis pain-related behaviours and inflammation in rats, without any evident side-effects.

The study involved the use of 0.6, 3.1, 6.2, 62.3 mg/day CBD gels on rats for 4 consecutive days after arthritis induction. Immunohistochemical analysis of the subject’s spinal cord and dorsal root ganglia revealed dose-dependent reductions of pro-inflammatory biomarkers and, therefore, a decrease in the level of inflammation.

Studies have also found that the use of CBD can help treat diabetes. Data from a 2008 study indicated that 11–14-week-old female mice, either in a latent diabetes stage or with initial symptoms of diabetes, when treated with CBD for 4 weeks, led to sustained inhibition of insulitis.

The study showed that CBD treatment inhibited specific destruction of the islets and reduced the infiltrates by mononuclear cells into the islets, thus preventing diabetes.

In another study that was conducted in 2012, researchers indicated that CBD had anti-inflammatory effects in a murine model of acute lung injury. The study, which involved a single dose of 20mg/kg CBD, administered prior to the induction of the inflammatory disease, showed that CBD administration caused an increase in the extracellular adenosine and signaling through adenosine A(2A) receptor, which contributed to its anti-inflammatory properties.

Studies have also shown that CBD suppresses inflammatory and neuropathic pain by targeting α3 glycine receptors.

What Are The Benefits of Using CBD for Inflammation?

Benefits of Using CBD for InflammationCBD has a number of benefits when using it for inflammation. Some of these are mentioned below;

  • CBD provides instant pain relief.
  • You do not need to take Opiates for pain relief.
  • There is a reduced need for taking NSAIDs which are known for causing gastric ulcers.
  • The side effects are reduced as compared to the usage of Opiates and steroids.
  • CBD reduces inflammation in such a way that the person is able to restore his daily activities.
  • Reduction in inflammation also helps in better sleep.

What Is The Best CBD Dosage To Treat Inflammation – User Reviews?

Because inflammation can be caused due to different reasons, CBD dosage depends greatly upon the type of inflammation (acute or chronic), the severity of the condition and the time of onset of symptoms.

Ideally, it is always recommended to start with a small dosage, which could be increased gradually until the desired results are reached. In the case of mild inflammation, patients are advised to start with about 20 to 30mg CBD.

This dosage is usually effective in delivering the anti-inflammatory properties of the compound and alleviating the signs of inflammation.

In some cases, however, when the inflammation is of a very severe level, such as in the inflammatory disorder, Crohn’s disease, patients may take up to 50mg as the starting dosage. To achieve the desired effects, this amount can be increased up to even 100mg of CBD.

A patient, suffering from Crohn’s disease, commented on the social forum Reddit, saying “A dosage of 50-80mg/day CBD isolate in caps, helps with my Crohn’s disease immensely.”

Many users on the forum, however, believed that starting small was probably the best way to get around with CBD dosage.

One user stated, “A little bit goes a long way with this stuff, you really don’t need much at all.”

While sharing their experiences, users stated that the drug was a miraculous remedy for both, inflammation, and the pain associated with the condition.

One user stated “I suffer from inflammation and am always in some form of pain. I wanted to stop using Advil because it wasn’t helping much. I started with 20mg CBD capsule. It takes about an hour to get in my system and the pains either lessen or disappear, depending on the day and level of activity I did the day before. When I am in a lot of pain, I’ve taken up to 2 capsules, 60mg for the day and it has taken my pain away.”

Another user, while commenting about his dosage regime commented “I started with 20mg. Now I take 40mg a day, but when the inflammation is bad I have to take 60mg of CBD.”

Users also compared the cannabinoid to prescribed medicines, stating that CBD provided better results and had potentially no side-effects.

One user expressed “I had back surgery due to which I have lingering inflammation on the L5 disc and my right hip. I started with about 20-25 mg CBD per day and eventually settled on 50mg per day. I think the only time in the last 1.5 years that I have taken ibuprofen was from a hangover I couldn’t conquer.”

Patients who had sought CBD products to treat pain and inflammation were more than satisfied with the results. They compared CBD’s non-psychoactive properties to that of THC, arguing that while the latter had dosage-dependent pro and anti-inflammatory effects, CBD showed anti-inflammatory effects at all dosages.

A user commented “I think CBD Is the anti-inflammatory in weed. You won’t get high, it’s non-psychoactive so it can actually sober you up, inflammation will go down in seconds, it’s a neural fortifier, and mood stabilizer.”

Are There Any Side Effects When Using CBD for Inflammation?

For example, if you are taking CBD for arthritis, you will be conscious about the side effects. This is very much necessary as any substance may cause interaction with any drug.

Using CBD at high doses may give you unwanted effects such as upset stomach, drowsiness, sedation, diarrhea and dry mouth.

There are no reported extreme side effects of CBD. It is suggested that you take CBD at low doses to avoid any unwanted effects.

Conclusion on CBD for Inflammation

Scientific research has shown promising results regarding the use of CBD for inflammation. The compound is non-psychoactive, and therefore, legal in many states. It is a relatively safer substitute for prescribed medications as it does not pose any risks of overdose. In addition to this, the amount of CBD intake can always be reduced if a person feels they’re taking too much without the fear of any withdrawal symptoms.

See References:
  • https://en.wikipedia.org/wiki/Inflammation
  • https://www.ncbi.nlm.nih.gov/pubmed/10920191/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
  • https://www.ncbi.nlm.nih.gov/pubmed/17714746/
  • https://www.ncbi.nlm.nih.gov/pubmed/26517407
  • https://www.ncbi.nlm.nih.gov/pubmed/22265864
  • https://idweeds.com/cbd-for-inflammation/
  • https://www.reddit.com/r/CBD/comments/65vc4k/inflammation_dosage/
  • https://www.reddit.com/r/CBD/comments/5tuqs3/cbd_for_antiinflammation_vs_thc/
  • Burstein S. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & medicinal chemistry. 2015 Apr 1;23(7):1377-85.
  • Booz GW. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radical Biology and Medicine. 2011 Sep 1;51(5):1054-61.
  • Liou GI, Auchampach JA, Hillard CJ, Zhu G, Yousufzai B, Mian S, Khan S, Khalifa Y. Mediation of cannabidiol anti-inflammation in the retina by Equilibrative nucleoside transporter and A2A adenosine receptor. Investigative ophthalmology & visual science. 2008 Dec 1;49(12):5526-31.
  • Mecha M, Torrao AS, Mestre L, Carrillo-Salinas FJ, Mechoulam R, Guaza C. Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress. Cell death & disease. 2012 Jun;3(6):e331.
  • Burstein SH, Zurier RB. Cannabinoids, endocannabinoids, and related analogs in inflammation. The AAPS journal. 2009 Mar 1;11(1):109.
  • Mecha M, Feliú A, Iñigo PM, Mestre L, Carrillo-Salinas FJ, Guaza C. Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors. Neurobiology of disease. 2013 Nov 1;59:141-50.
  • Jamontt JM, Molleman A, Pertwee RG, Parsons ME. The effects of Δ9‐tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. British journal of pharmacology. 2010 Jun 1;160(3):712-23.
  • Rajesh M, Mukhopadhyay P, Bátkai S, Patel V, Saito K, Matsumoto S, Kashiwaya Y, Horváth B, Mukhopadhyay B, Becker L, Haskó G. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. Journal of the American College of Cardiology. 2010 Dec 14;56(25):2115-25.
  • Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Haskó G, Pacher P. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. Journal of Pharmacology and Experimental Therapeutics. 2009 Mar 1;328(3):708-14.
  • Costa B, Giagnoni G, Franke C, Trovato AE, Colleoni M. Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. British journal of pharmacology. 2004 Sep 1;143(2):247-50.
  • Ribeiro A, Almeida VI, Costola-de-Souza C, Ferraz-de-Paula V, Pinheiro ML, Vitoretti LB, Gimenes-Junior JA, Akamine AT, Crippa JA, Tavares-de-Lima W, Palermo-Neto J. Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury. Immunopharmacology and immunotoxicology. 2015 Jan 2;37(1):35-41.
CBD For Inflammation: Benefits, Scientific Studies, & CBD Dosage For Inflammation
5 (100%) 3 votes