Have you been finding yourself lazy when you wake up in the morning? Drinking coffee helps tremendously along with waking up at the alarm, but do you feel something is missing? That something is Kratom. Now, what is kratom?
Kratom is a type of tropical tree found in Southeast Asia. The leaves of kratom have a long history and have been in use for relieving pain. You can consume them in raw form, crush them and brew them as a tea.
These leaves can also be consumed as tablets, capsules or liquids. High doses of kratom act as a sedative agent while small doses act as a stimulant. Kratom can also result in psychological addiction along with psychotic symptoms. Few cases of kratom use have been reported to be life-threatening.
Kratom has been used to treat depression, pain, and anxiety. It is claimed that it helps to treat chronic pain and helps in combating addiction to opiate medicines.
The DEA previously announced the kratom as a schedule 1 drug which is the same as heroin or marijuana. However, the decision was delayed, but the agency states that kratom possesses a high abuse potential and has no medical use in current situations.
Mechanism of action of Kratom
Many studies have been carried out to find out the mechanism of action of kratom. An experiment was done in mice where kratom targeted the part of the brain which response to opioid drugs such as codeine, morphine, and fentanyl.
Kratom is a synthetic compound derived from mitragynine pseudo-indoxyl which does not produce side effects like respiratory depression, physical dependence, and constipation that are the leading side effects with most of the opioids.
Effects of drug Kratom
Kratom is a type of new drug in Europe and US. Kratom has been used in Southeast Asia for many years as a painkiller, anti-diarrheal medicine and as a recreational drug. It is a favorite tree and drug is extracted from its leaves.
The effects of kratom last for around 5-7 hours, but high doses may last longer. Kratom is promoted as an undetectable, legal and safe drug. The breakdown yields of kratom are detected in drug tests which make it illegal in the US.
Kratom is included in a new class of drugs i.e. New Psychoactive Substances with other drugs such as khat, Salvia Divinorum along with mephedrone.
The kratom drug has been said to abuse for its stimulating and sedative effects. When taken in small doses it stimulates a person making him more sociable, talkative and energetic while at higher doses it results in euphoria and lethargy.
Adverse effects of Kratom
The undesirable effects include: vomiting, edginess, nervousness, nausea, sweating, itching, delusions, constipation, lethargy, tremors, aggressive behavior, high doses may result in respiratory depression, paranoia, hallucinations.
Additional effects are a loss of weight and sexual desire, darkening of face and skin, constant cravings for more drug consumption.
Withdrawal effects of Kratom
These results are similar to other opioids i.e. muscle pain, diarrhea, tremors, jerking, depression, panic, and irritability. 
How to consume Kratom with Coffee?
There are three ways for its consumption:
- Mix kratom and coffee and add some sugar along with a creamer.
- Drink your coffee first before an hour of consumption of kratom.
- Prepare kratom tea if kratom leaves are available and mix coffee in it.Boil around 1-2 cups of water in a saucepan and add 10-15grams of kratom leaves in it. Then boil the water for 15-20 minutes at low heat. After cooking strain the tea and mix it with coffee.
All three have the same effects, and there isn’t much difference if you utilize either way. The first option is better because kratom has a disgusting taste, so the coffee acts as a masking agent for its bitterness.
The combination of kratom and coffee works well as both the compounds help in kicking the day with alertness and positive feelings. You will feel energetic throughout the day even if you hit the gym. Coffee is said to possess the fat burning properties. [2,4,5,6]
Avoid brewing the kratom at high heat because it results in denaturing effects of alkaloids. After you have boiled the water, let it sit for 1-2 minutes and add the required amount of coffee and kratom powder.
Stir the powder completely until it dissolves. You can consume a combination of iced coffee along with kratom.
Coffee & Kratom doses
For small doses consume 1-2 grams of kratom while for medium doses consume around 2-5 grams. You can use coffee according to your desired amount.
Avoid high doses of coffee as it results in adverse effects that are around 0.5-1.5 grams. If your tolerance level is high for coffee consumption, then you can consume it. 
Does coffee work well with Kratom?
The combination of coffee and kratom has synergic effects. Both of them have the ability to act as psychomotor stimulants which act primarily and aid in stimulation of central nervous system. These stimulants result in euphoria, excitement, reduces the feeling of fatigue and helps in increasing the motor activity.
Thus, the mixture of kratom and coffee results in potentiating the effects of both the drugs. It is a great combination and leads to alertness and activation of well-being state both mentally and physically. [4,6]
What is the mechanism of action of coffee?
Coffee consists of methyl xanthine which is also termed as caffeine, and it is the most extensively used stimulant.
There are different mechanisms of caffeine. It causes the translocation of calcium which is extracellular present and results in increased levels of cyclic guanosine monophosphate and cyclic adenosine monophosphate which are produced by blocking adenosine receptors and interfering with phosphodiesterase.
The increased levels of cAMP and cGMP help in enhancement of stimulatory effects along with inhibition of enzyme i.e. phosphodiesterase which prevents the damage of these second messengers.
Effects of coffee on human body
Coffee in small doses such as one to two cups increases the mental sharpness along with the reduction of fatigue and acts as a stimulating agent on the cortex and other parts of the brain. However coffee in high doses i.e. 13-15 cups (1.5 gm.) results in tremors and anxiety.
Caffeine can also stimulate the spinal cord at high doses i.e. around 3-5 grams. The high dosage of caffeine acts on the heart and results in rapid contraction and beating with a strong force.
It has a mild diuretic action which results in increased urine output of chlorine, sodium, and potassium along with HCL. It also helps in relaxation of bronchioles.
Combination effects of Kratom and Coffee
The combination results in stimulatory effects. Avoid high doses as it results in sedation, and small doses produce stimulatory effects. So it is advised to take small doses of kratom otherwise the coffee will negate the stimulatory effects of kratom.
Beneficial effects with coffee
- Coffee helps in losing weight and reduces the appetite to ingest sugary food.
- It helps in boosting the physical performance due to the enhancing effect of
- The coffee intake helps in burning fat and fighting depression.
- It improves focus and mental alertness.
- It reduces the death rate by lowering the risk of stroke, cancer, Type 2 diabetes and Parkinson’s
- It has an antioxidant function within the body.
- The coffee consumption helps in memorizing stuff which results in prevention of dementia along with Alzheimer’s disease. [4,6]
The moderate amount of coffee consumption results in anxiety, insomnia, and agitation. However high doses cause toxicity, convulsions, and emesis. The lethal dose of 10g induces cardiac arrhythmias. High doses of around 600mg may lead to lethargy, headache, and irritation. 
How can you potentiate Kratom effects?
The potentiators help in enhancing the potency and strength of small doses of kratom. You can achieve maximum results or potentiate the effects of kratom by following items:
- Food which includes grapefruit juice, turmeric, cayenne pepper and watercress (a type of lettuce).
- Supplements contain caffeine which is referred to as the potentiators of drug kratom and helps in combating sluggishness. Other supplements include cat’s claw and Valerian.
- Tea which includes preparation of kratom tea or mixing kratom with other herbal teas. You can also add chamomile tea or passion flower to increase the soothing effects. [7,8]
What is the role of potentiators?
The potentiators work by moderating the metabolism levels and focus on an enzyme i.e. Cytochrome P450.
There is a breakdown of the kratom alkaloids and expulsion process takes place with the help of cytochrome P450 enzyme within the system. The foods which reduce the functioning of this enzyme will eventually extend the kratom effects.
Does coffee potentiate the effects of fast & slow Kratom?
Coffee helps in boosting the effects of fast kratom strains i.e. the white-vein type. The slow strains of kratom are relaxing strains i.e. the red-vein variety. It helps as a relaxing agent, produces the feelings of euphoria along with the reduction of anxiety. Coffee enhances the energy level by drinking the slow strains. 
Drinking coffee pairs well with kratom especially the slow strains. It helps in counteracting the drowsy effects of kratom and enhances the effects of anti-anxiety and well-being. Avoid any health issues by getting a proper sleep and maintaining an appropriate diet plan.
Initially, start with small doses of both coffee and kratom and gradually increase the dose. If you start consuming high dose in the initial phase, you may end up in vomiting. You can suffer from stomach upset if you avoid adding sugar and creamer with kratom. You can enjoy the benefits of this combination but be very careful.
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