Opiate addiction has been causing problems all over the world. The increasing number of cases for Opiate addiction has been alarming for the US government, and thus they have labeled it as the Opiate crisis.
In this regard, the U.S. government is trying every possible measure to get rid of this crisis. The governmental, as well as non-governmental agencies related to public health, have joined hands in this venture to eradicate this crisis.
With a lot of research going on, on different drugs combat Opiate addiction, one cannot possibly deny the existence of CBD Cannabis and Kratom.
The FDA may not approve this substance at the moment, but it is the requirement of time to consider them as possible options in the reduction of Opiate addiction rates.
What Is The Role of Kratom in Reducing Opiate Addiction?
We are well aware of the fact that Kratom acts on Opiate receptors in the brain. The Opiate receptors come in 3 forms, mu, delta and kappa.
Kratom acts on all three types of receptors. But there is a difference in the actions produced by Kratom and by Opiates.
Opiates cause addiction. They create dependence and quick development of tolerance. On the other hand, Kratom doesn’t cause any addiction.
Kratom reduces Opiate addiction by easing the Opiate withdrawal symptoms. These symptoms are so intense that the person is bound to revert to Opiate addiction.
The Opiate withdrawal symptoms include anxiety, mood swings, pain etc. These symptoms are dealt with by Kratom without causing addiction.
Throughout Malaysia, the Kratom tea made from crushed leaves are traditionally used to reduce opiate withdrawal or pain. But, in the US the Kratom is sold and consumed in the form of powder, capsules, extracts, tinctures, and even energy drinks.
On YouTube, FB groups, and online forums like Bluelight or Reddit, there are thousands of positive reviews about Kratom for opiate withdrawal.
According to a study of a 43-year-old man published in 2008 by the Edward W. Boyer and co-researchers, the man has managed opioid withdrawal with Kratom purchased from online vendors. The Man claims that Kratom doesn’t produce any adverse effects as someone usually experience with opioid use.
Christopher McCurdy, a medicinal chemist and an internationally recognized expert on Kratom, investigates that two essential alkaloids mitragynine and 7-hydroxymitragynine bond to the body’s opioid receptors just like opioids but they aren’t much potent like prescription opioids.
McCurdy conducted an experiment with his colleagues where they have repeatedly dosed the mice with morphine. The study on mice revealed that the extracts of pure mitragynine doesn’t cause any side-effects and have completely blocked the morphine withdrawal symptoms.
McCurdy studies also indicate that the Kratom plant has very low abuse potential and doesn’t slow breathing or create respiratory depression.
What Is The Role Of CBD Cannabis In The Reduction Of Opiate Addiction?
CBD Cannabis basically acts on these receptors to reduce Opiate addiction;
- Cannabinoid receptor
- Dopamine receptor
- Opioid receptor
- Serotonin receptor
CBD Cannabis is an important option when it comes to Opiate addiction treatment. When CBD reacts with cannabinoid receptors, it helps in reduction of the craving for Opiates.
It also directly interacts with Opioid receptors and help in the management of pain and anxiety. When it reacts with Dopamine receptors, it helps in fighting Opiate addiction and acts as an antidepressant by releasing large amounts of dopamine.
It also acts directly with the serotonin receptors and helps in reducing Opiate addiction, anxiety as well as depression.
This action is brought about by inducing the release of large quantities of serotonin, which along with dopamine activates the reward and pleasure centre of the brain.
CBD’s interaction with the serotonin receptors blocks the reward-seeking effects of Opiates, so the craving for Opiates is eventually reduced.
Researchers are conducting studies to add CBD cannabis into the ‘opioid exit-treatment list’ as many theories about the efficacy of CBD cannabis are circulating. One such theory is laid down by Blue Door Therapeutics in Scottsdale. The doctors say that CBD Cannabis has helped patients by relieving their nausea and many other opioid withdrawal symptoms by blocking the effects of opiates on the brain receptors.
What Is The Role Of CBD Hemp In The Reduction Of Opiate Addiction?
CBD derived from hemp doesn’t contain the entire range of cannabinoids in it thus for Opiate reduction it is mildly helpful. It can only give the taste of CBD Cannabis to those persons who can’t obtain CBD Cannabis due to legal regulations. CBD hemp can mildly reduce the craving and withdrawal symptoms of Opiate addiction. It can relieve pain and anxiety to some extent but to experience full effects, CBD Cannabis is the choice of substance for Opiate reduction.
User Reviews About CBD Cannabis
Mandile tells his story in a blog. He says that back then in 2012 he used to sleep only 2 hours a day and would wait desperately for his next dose of Opiates.
He found out that a substance known as CBD cannabis could help him with this condition. He narrated that he got addicted to Opiates because he was using them for pain management.
The pain was there due to injuries inflicted during a motor collision in the Iraq war. Being a military person, he had to get back to work quickly, but with this amount of pain and injuries he couldn’t. This made him depressed. He was just 28.
He started taking Opiates and then his life was even more ruined. He recounts “I was a Zombie.” This was when Mandile decided to take CBD to get rid of the Opiate addiction.
He heard that CBD cannabis has promising effects and it reduces Opiate addiction substantially, at the same time managing symptoms like pain and depression.
Clinical Studies About CBD Cannabis
In one double-blind placebo-controlled trial, CBD was administered to patients with Opiate addiction, and the results were terrific. It was well-tolerated and without any side effects.
Many other similar studies conducted in which the effects of CBD were measured.
A study was conducted in 2016 which surveyed the use of medical cannabis in 244 patients in Michigan. The use of medical cannabis was related to an overall 64 percent decrease in the use of Opiates and a 45 percent improvement in the quality of life was observed. This means Cannabis is a safe hub when it comes to using it for Opiate withdrawal.
A similar study was conducted in Israel the same year which showed amazing results. 44 percent patients out of 176 Opiate addicts were able to discontinue the use of Opiates after using Cannabis therapy for 7 months.
Why Should One Go For Kratom And CBD Cannabis?
We all are aware of the fact that so far Kratom has not produced any fatality, same is the case with CBD.
Most of the other drugs present in the market have severe adverse effects, and they cannot be treated.
Most of all, Kratom and CBD do not cause addiction and produces very low tolerance or even no tolerance. Both substances are entirely safe if taken in the right dose and not mixed with other substances.
How Can Kratom And CBD Cannabis Be Used?
Kratom can be taken in the form of powder, tablet, capsule, drink or even vaped but the best way is to use it in powder form.
The extracts and tinctures are usually not recommended for alleviating Opiate addiction. CBD can be taken in the form of vapers, tinctures, BHO, RSO and topical solution.
What Is The Stance Of FDA About Kratom And CBD Cannabis?
FDA isn’t pleased with the idea of Kratom for Opiate withdrawal, because the research done on Kratom is too less.
However, many governmental organizations and public health agencies are inclined towards the use of CBD for Opiate withdrawal which is also making the FDA think about approving it for medication.
Kratom and CBD Cannabis are effective options for treating Opioid addiction.
They act by;
- Reducing addiction to Opiates
- Preventing relapse from occurring
- Reducing cravings for Opiates
- Effectively treat the withdrawal symptoms
- Improves mood
- Enhances body energy levels
- Reduces fatigue, anxiety, stress, and depression
- Cannabis and Kratom are considered as spirit medicine
These two substances do not cause any significant side effects and can help with Opiate addiction. The government is urged to legalize these substances so that they can be easily made available and their use is regulated.
Also, it is recommended to promote more research about these substances to get to know their full potential.See References:
- Volkow ND. America’s Addiction to Opioids: Heroin and Prescription Drug Abuse. The Science of Drug Abuse & Addiction 2014.
- Hurd YL, Yoon M, Manini AF, et al. Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage. Neurotherapeutics. 2015;12(4):807-815.
- Gaviria M. Chasing Heroin 2016.
- Katsidoni V, Anagnostou I, Panagis G. Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus. Addict Biol. 2013;18(2):286-296.
- Ren Y, Whittard J, Higuera-Matas A, Morris CV, Hurd YL. Cannabidiol, a non-psychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances. J Neurosci. 2009;29(47):14764-14769.
- Linda R. Gowing RLA. The place of detoxification in the treatment of opioid dependence. Current Opinion in Psychiatry. 2006;19:266-270.
- Manini AF, Yiannoulos G, Bergamaschi MM, et al. Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans. J Addict Med. 2015;9(3):204-210.
- Prudhomme M, Cata R, Jutras-Aswad D. Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence. Subst Abuse. 2015;9:33-38.