What is the Right Dosage of Noopept?

Noopept also was known as GVS-11, and N-phenylacetyl-L-prolylglycine ethyl ester is essentially a Nootropic (smart drugs or cognitive enhancers which are responsible for enhancing cognitive function). It works as a prodrug of cycloprolylglycine, needing to be activated metabolically before it can start its function. This drug was initially synthesized in Russia, where its mechanism of action was not understood well enough.

Starting from 2017, experimental trials on cells and animal models have been underway which have shed more light on the potency and efficacy of this drug [1].

Noopept is comparable to piracetam in its effects. Similar to Piracetam, Noopept can provoke a mild cognitive effect, improvement in memory and psychostimulatory effects.

Medicinal benefits

Noopept provides benefit to the human mind by the achievement of the following abilities [2]:

  • Prompt formation of memory
  • Better memory recall
  • Improved learning
  • Retained information
  • Better focus and attention span
  • Clear concepts
  • Increased productivity levels
  • Decreased stress levels
  • Higher motivation levels

Uses of Noopept

  • Memory and learning

One of Noopept’s most important effects is its ability in forming memories and improved learning process. Noopept has the additional benefit of building new memories and retrieving old memories, a benefit which does not exist with Piracetam.

This same mechanism also works in the way of making processing of information easier. This was forgetfulness will soon be minimized. The main way this benefit occurs is by an increase in neurotrophic factors which demonstrates a long term memory improvement [3].

  • Alleviation of anxiety

Noopept has anxiolytic effects which can be explained by tonic inhibition of the hippocampus. It has a unique role in anxiety which stems from cognitive impairment. It also helps alleviate feelings of fatigue, irritability, and annoyance.

  • Increased levels of NGF

Nerve growth factor is a protein produced by the living body which is involved in neurogenesis; a formation and perseverance of neurons.

  • Neuroprotective properties

Noopept exhibits neuroprotective properties by stimulating neurons. This stimulation hampers oxidative damage and apoptosis in the human brain. This function of Noopept has had a leading role in helping patients with cognitive impairment and deterioration.

  • Increased levels of BDNF

Brain-derived neurotrophic factors are similar in function to NGF. They have a key role in short-term and long-term memory.

  • Increased association between both the hemispheres

The human brain is divided into two hemispheres (right and left), which function correctly when both work in congruence with each other. Continued use of Noopept leads to enhancement of this association and stimulates better brain function by the generation of innovative ideas and memories [4].

Side effects

Data collected about the adverse effects of Noopept is still incomplete and being processed. At this point, the only data collected about Noopept has exhibited it as a drug with low levels of toxicity and high effectiveness. Some of the usual side effects noticed up till now are the following:

  1. Headaches
  2. Irritability
  3. Fatigue
  4. Insomnia
  5. Nausea
  6. Other gastrointestinal problems

These side effects might or might not occur uniformly in every individual and are probable to vary. Tolerance withdrawal effects are not severe [5].

Caution is advised while taking Noopept with Acetaminophen, as side effects are bound to occur.

How to use?

Noopept may be injected or taken orally. It can pass the blood-brain barrier which observed due to lack of difference in serum and neural concentrations of Noopept. Oral ingestion results in quick absorption but studies have shown that oral dose is equivalent to only about one-tenth of an injected dose. It is advised to start at the lowest possible dosage of Noopept, and gradually build it over time. It is available in both powder and capsules form [2].

Is it water soluble?

An effective level of Noopept can be maintained by mixing it in water and ingesting it, as it is water soluble.

Noopept dosage

Noopept should be started by low doses of around 5 mg two or three times a day. This way, the dosing will eventually increase to 40mg per day.

Keeping this in mind, under no circumstances should the dose go over 20 mg three times a day, for doing so will encourage overstimulation of glutamate receptors.

An effective and safe dose is supposed to be between 10- 30 mg per day, taken for up to 56 days at a time. [3]

Noopept dosage according to a teaspoon?

According to standard weights, one teaspoon contains 4 grams. According to these set standards, two and a half teaspoons of Noopept contains around 10gm of Noopept.

To achieve the already mentioned dosing of Noopept, around 1/8 filled part of Noopept is to be used, which will amount to around 10 mg [4].

For more accurate dosage, it is advised to use micro scoops (10 mg per scoop) or electronic scales [5]. In matters of calibration, electronic scales are believed to be the most reliable.

Noopept stacking

Noopept exhibits the phenomenon of stacking, which is working well in a synergistic way with other drugs.

  • Stacking with Piracetam and Choline

Noopept and Piracetam work well together for the sole reason that they work in a comparable manner but on different receptors; glutamate and acetylcholine, respectively.

Choline added to this stack has an even more efficient use. It has the additional benefit of avoiding the onset of a headache. Noopept is stacked with piracetam and choline in the following dosage (1 x2x day):

  • 10 mg Noopept
  • 2 gm Piracetam
  • 300 mg Alpha GPC
  • Stacking with Aniracetam and Sulbutiamine

Stacking Noopept with Aniracetam and Sulbutiamine results in an extraordinary stack that increases cognition, mood and decreases anxiety. Stacking is done by the following dosage (1x2x day)

  • 10 mg Noopept
  • 1 gm Aniracetam
  • 300mg Sulbutiamine
  • 300 mg Alpha GPC [6]

Dosage according to user reviews

A user taking 10 mg of Noopept in the morning and evening, which was later on increased to 20 mg reported mental clarity, energy, focus, elevated mood levels, and improved sleep [7].

Another user on Reddit, taking 15 mg of Noopept twice daily reported similar cognitive effects, but the withdrawal symptoms reported were a matter of concern.

The user reported serious depression with borderline suicide ideation and intense feelings of coldness and indifference to the people around him [8].

A user reported using 10 mg of Noopept sublingually. The first effect she experienced was increased visuals like watching television in High Definition.

She also reports improved mental clarity due to which she finished her workload in half the time, increased multi-tasking ability and an increase in vocabulary.

She reported occasional demotivational feelings, headaches, and irritability [9].

Is it legal?

The use of Noopept still has not been approved by the credible Food and Drug Authority (FDA). The European Medicines Agency either has not approved its use. Keeping this in mind, a lot of work and research is needed before Noopept can join the ranks of approved drugs [10].

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